On-Demand Tramadol Hydrochloride Use in Premature Ejaculation Treatment

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dc.contributor.authorKaynar, Mehmet
dc.contributor.authorKılıç, Özcan
dc.contributor.authorYurdakul, Talat
dc.date.accessioned2020-03-26T18:30:58Z
dc.date.available2020-03-26T18:30:58Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOBJECTIVES To determine the efficacy of tramadol in premature ejaculation (PE) treatment compared with placebo. METHODS A single-blind, placebo-controlled, crossover study was conducted with 60 lifelong (primary) patients with PE. The patients were randomized into 2 groups, each consisting of 30 patients, who took tramadol or placebo on demand. PE was defined as an intravaginal ejaculation latency time of <= 60 seconds in 90% of intercourse episodes. The efficacy of the drugs was assessed using the intravaginal ejaculation latency time, ability of ejaculation control, and sexual satisfaction scores after an 8-week treatment period. RESULTS All participants completed the study voluntarily. Two groups were similar in terms of the patient demographics. Increases in the intravaginal ejaculation latency time, ability of ejaculation control, and sexual satisfaction score between the placebo and tramadol groups were compared with the baseline values in both groups. At the end of study period, the tramadol group had significantly (P<.001) greater values for all 3 parameters compared with those in the placebo group. CONCLUSIONS On-demand use of low-dose tramadol is effective for lifelong PE. Currently, selective seratonin reuptake inhibitors such as dapoxetine, are a more popular treatment option for PE. However, tramadol might be considered an alternative agent for primary PE treatment.en_US
dc.identifier.citationKaynar, M., Kılıç, Ö., Yurdakul, T., (2012). On-Demand Tramadol Hydrochloride Use in Premature Ejaculation Treatment. Urology, 79, 145-149. Doi:10.1016/j.urology.2011.09.031
dc.identifier.doi10.1016/j.urology.2011.09.031en_US
dc.identifier.endpage149en_US
dc.identifier.issn0090-4295en_US
dc.identifier.issue1en_US
dc.identifier.pmid22088571en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage145en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.urology.2011.09.031
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28273
dc.identifier.volume79en_US
dc.identifier.wosWOS:000298671000035en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaynar, Mehmet
dc.institutionauthorKılıç, Özcan
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofUrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleOn-Demand Tramadol Hydrochloride Use in Premature Ejaculation Treatmenten_US
dc.typeArticleen_US

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