New Perspectives on Asphodeline lutea from Bulgaria and Turkey: Anti-mutagenic, Anti-microbial and Anti-methicillin Resistant Staphylococcus aureus (MRSA) Activity

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dc.contributor.authorUysal, Ahmet
dc.contributor.authorLazarova, Irina
dc.contributor.authorZengin, Gökhan
dc.contributor.authorGüneş, Erdoğan
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorGevrenova, Reneta
dc.date.accessioned2020-03-26T19:25:19Z
dc.date.available2020-03-26T19:25:19Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAims: In this study, methanol extracts of Asphodeline lutea roots from Bulgaria (ALB) and Turkish (ALT) origin were evaluated for their anti-microbial, anti-MRSA properties and they were also screened for the potential of mutagenic and anti-mutagenic activities. Methodology: The broth micro dilution method was performed for the anti-microbial activities. For mutagenicity and anti-mutagenicity screening of the extracts, plate incorporation method of Ames test was employed. Results: Sarcina lutea was the most sensitive bacterium against ALB and ALT extracts at doses of 1.56 and 0.78 mg/ml, respectively. Both extracts exhibited similar activity against methicillin sensitive Staphylococcus aureus (MSSA) and Salmonella enteritidis with MIC value 6.25 mg/ml. Based on the results obtained from Ames test, no mutagenic activity was found for frame shift mutation (TA98) and base pair substitution (TA100) in all concentrations of A. lutea. Strong antimutagenic properties with rates of 77% and 75% were observed at the highest concentrations of both extracts against 2-aminofluorene-induced mutagenicity on TA 98 with the presence of metabolic activator S9 system. Conclusion: As a result, the extracts revealed significant anti-MRSA activity with MIC values 6.25 mg/ml against MRSA strains isolated from infections and manifested strong anti-mutagenic activity against known mutagens; it may be used in drug formulations against MRSA infections and may be used as a natural anti-mutagenic agent in the pharmacology and food industries.en_US
dc.identifier.doi10.9734/BJPR/2016/23957en_US
dc.identifier.issn2231-2919en_US
dc.identifier.issue3en_US
dc.identifier.pmid#YOKen_US
dc.identifier.urihttps://dx.doi.org/10.9734/BJPR/2016/23957
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33824
dc.identifier.volume10en_US
dc.identifier.wosWOS:000370145200002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSCIENCEDOMAIN INTen_US
dc.relation.ispartofBRITISH JOURNAL OF PHARMACEUTICAL RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAsphodeline luteaen_US
dc.subjectanti-MRSAen_US
dc.subjectanti-mutagenicen_US
dc.subjectnatural agenten_US
dc.titleNew Perspectives on Asphodeline lutea from Bulgaria and Turkey: Anti-mutagenic, Anti-microbial and Anti-methicillin Resistant Staphylococcus aureus (MRSA) Activityen_US
dc.typeArticleen_US

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