Pinealectomy and Zinc Deficiency Have Opposite Effects on Thyroid Hormones in Rats

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dc.contributor.authorBaltacı, Abdülkerim Kasım
dc.contributor.authorMoğulkoç, Rasim
dc.contributor.authorBediz, Cem Şeref
dc.contributor.authorKul, Aylin
dc.contributor.authorUğur, Ayşegül
dc.date.accessioned2020-03-26T16:45:57Z
dc.date.available2020-03-26T16:45:57Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe present study was conducted to investigate how pinealectomy and zinc deficiency separately or in combination affected thyroid hormones in rats. The study was carried out on 40 Sprague-Dawley male rats. The rats were equally allocated to four groups: Group 1 (control group), Group 2 (zinc-deficient group), Group 3 (pinealectomized group) and Group 4 (pinealectomized and zinc-deficient group). At the end of a 4-week study period, the rats were decapitated and blood samples were taken. The samples were examined in terms of plasma zinc, melatonin, free and total T-3, T-4, and TSH. It was found that free T-3 and T-4 levels in the pinealectomized group (Group 3) were higher than all others (p < 0.01) while free T-3, T-4, and TSH levels in the zinc-deficient group (Group 2) were lower than all others (p < 0.01). Free T3 and T4 levels in the pinealectomized zinc-deficient group (Group 4) were lower than those in Groups I and 3 and higher than those in Group 2 (p < 0.01). The findings obtained at the end of the study period show that pinealectomy has a stimulating and zinc deficiency has a suppressing effect on thyroid hormones and that the suppressing effect caused by zinc deficiency is partially balanced by pinealectomy.en_US
dc.identifier.citationBaltacı, A. K., Moğulkoç, R., Bediz, C. Ş., Kul, A., Uğur, A., (2003). Pinealectomy and Zinc Deficiency Have Opposite Effects on Thyroid Hormones in Rats. Endocrine Research, 29(4), 473-481. Doi: 10.1081/ERC-120026953
dc.identifier.doi10.1081/ERC-120026953en_US
dc.identifier.endpage481en_US
dc.identifier.issn0743-5800en_US
dc.identifier.issue4en_US
dc.identifier.pmid14682476en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage473en_US
dc.identifier.urihttps://dx.doi.org/10.1081/ERC-120026953
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18529
dc.identifier.volume29en_US
dc.identifier.wosWOS:000187163300011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBaltacı, Abdülkerim Kasım
dc.institutionauthorMoğulkoç, Rasim
dc.institutionauthorKul, Aylin
dc.institutionauthorUğur, Ayşegül
dc.language.isoenen_US
dc.publisherMarcel Dekker Incen_US
dc.relation.ispartofEndocrine Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPinealectomyen_US
dc.subjectZinc Deficiencyen_US
dc.subjectThyroid Hormonesen_US
dc.subjectRaten_US
dc.titlePinealectomy and Zinc Deficiency Have Opposite Effects on Thyroid Hormones in Ratsen_US
dc.typeArticleen_US

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