Catalytic effect of calix[n]arene based sol-gel encapsulated or covalent immobilized lipases on enantioselective hydrolysis of (R/S)-naproxen methyl ester

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dc.contributor.authorErdemir, Serkan
dc.contributor.authorYılmaz, Mustafa
dc.date.accessioned2020-03-26T18:24:13Z
dc.date.available2020-03-26T18:24:13Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this paper the catalytic performance of the immobilized lipases was investigated in the presence of calixarene based polymers using different immobilization techniques. For this reason, Candida rugosa lipase was encapsulated in sol-gel matrices using alkoxysilane precursors and calix[n]arene based silica polymers as additives. The hydrolytic activities of encapsulated lipases were evaluated and compared with the free lipase and covalently immobilized lipases (CnP-L). These encapsulated lipases were also used in the kinetic resolution of the R/S-Naproxen methyl ester. The results indicated that the C6P encapsulated lipase has significantly higher conversion and enantioselectivity as compared to the free lipase; other encapsulated lipases and CnP-L. The optimal pH and temperature region of the C6P encapsulated lipase in the kinetic resolution of the R/S-naproxen methyl ester were 7.0 and 55 A degrees C. Nevertheless, the encapsulated lipases have good stability, adaptability and reusability in comparison with the free enzyme.en_US
dc.description.sponsorshipResearch Foundation of Selcuk University (BAP)Selcuk University; Scientific and Technical Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [106T435]en_US
dc.description.sponsorshipWe would like to thank The Research Foundation of Selcuk University (BAP) and The Scientific and Technical Research Council of Turkey (TUBITAK-Grant Number 106T435) for financial support of this work.en_US
dc.identifier.doi10.1007/s10847-011-9962-1en_US
dc.identifier.endpage196en_US
dc.identifier.issn1388-3127en_US
dc.identifier.issn1573-1111en_US
dc.identifier.issue01.02.2020en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage189en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10847-011-9962-1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27808
dc.identifier.volume72en_US
dc.identifier.wosWOS:000299930600020en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofJOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCalixarenesen_US
dc.subjectSilicaen_US
dc.subjectNaproxeneen_US
dc.subjectEnantioselectivityen_US
dc.subjectSol-gelen_US
dc.titleCatalytic effect of calix[n]arene based sol-gel encapsulated or covalent immobilized lipases on enantioselective hydrolysis of (R/S)-naproxen methyl esteren_US
dc.typeArticleen_US

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