Effects of Diphenhydramine Hc1 and Methylprednisolone in the Prevention of Abdominal Adhesions

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dc.contributor.authorAvşar, Fatih Mehmet
dc.contributor.authorŞahin, Mustafa
dc.contributor.authorAksoy, Faruk
dc.contributor.authorAvşar, A. Filiz
dc.contributor.authorAköz, Mehmet
dc.contributor.authorHengirmen, Süleyman
dc.contributor.authorBilici, Sami
dc.date.accessioned2020-03-26T16:37:06Z
dc.date.available2020-03-26T16:37:06Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The purpose of this study was to determine the effects of diphenhydramine hydrochloride and methylprednisolone in peritoneal adhesions. Materials and methods: Forty-eight male rats were used in the study. The rats were anesthetized by 5 mg/kg ketamine hydrochloride. After opening the abdomen, 10 longitudinal incisions of 2 to 3 cm in length were made on the right parietal peritoneum, and a 2 cm(2) peritoneal layer was excised from the left abdominal wall. The abdomen was closed with 3/0 silk suture. Group I was the control group. group II was given 10 mg/kg diphenhydramine intravenously, group III was given 20 mg/kg methylprednisolone intravenously, and group IV was administered both of the drugs in the above doses. A blood sample of 2 mL was taken from the rats on the 14th day after the operation. The animals were then sacrificed. The abdomen was opened and abdominal adhesions were examined. A tissue sample of 1 g was taken from the abdominal incision line, Albumin. zinc, and hemoglobin levels and leucocyte counts in the blood were determined as well as hydroxyproline levels in the tissue. Results: Numbers of adhesions were as follows: 9 in group 1, 3 in group II and 2 in group III. No adhesion was observed in group IV. Albumin, zinc, and hemoglobin levels and leucocyte counts were found to be similar in all groups. Hydroxyproline levels in the tissue were significantly lower in groups III and IV than in groups I and II (P < 0.05). Conclusions: Diphenhydramine and methylpredrisolone reduced postoperative adhesions significantly in rats. Further investigations are needed in order to use these drugs as antiadhesive agents in humans.en_US
dc.identifier.citationŞahin, M., Aksoy, F., Aköz, M., Bilici, S., Avşar, F. M., Avşar, A. F., Hengirmen, S., (2001). Effects of Diphenhydramine Hc1 and Methylprednisolone in the Prevention of Abdominal Adhesions. American Journal of Surgery, 181(6), 512-515. Doi:10.1016/S0002-9610(01)00617-1
dc.identifier.doi10.1016/S0002-9610(01)00617-1en_US
dc.identifier.endpage515en_US
dc.identifier.issn0002-9610en_US
dc.identifier.issue6en_US
dc.identifier.pmid11513775en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage512en_US
dc.identifier.urihttps://dx.doi.org/10.1016/S0002-9610(01)00617-1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17536
dc.identifier.volume181en_US
dc.identifier.wosWOS:000170499700007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorŞahin, Mustafa
dc.institutionauthorAksoy, Faruk
dc.institutionauthorAköz, Mehmet
dc.institutionauthorBilici, Sami
dc.language.isoenen_US
dc.publisherEXCERPTA MEDICA INCen_US
dc.relation.ispartofAmerican Journal of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPostoperative Adhesionen_US
dc.subjectlleusen_US
dc.subjectInfertilityen_US
dc.subjectDiphenhydramine Hydrochlorideen_US
dc.subjectHydroxyproloneen_US
dc.subjectMethylprednisolone
dc.titleEffects of Diphenhydramine Hc1 and Methylprednisolone in the Prevention of Abdominal Adhesionsen_US
dc.typeArticleen_US

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