Leptin, insulin and body composition changes during adjuvant taxane based chemotherapy in patients with breast cancer, preliminary study

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dc.contributor.authorAlacacıoğlu, Ahmet
dc.contributor.authorKebapçılar, Levent
dc.contributor.authorGökgöz, Z.
dc.contributor.authorÖztekin, O.
dc.contributor.authorBozkaya, Giray
dc.contributor.authorTarhan, Oktay
dc.contributor.authorSomalı, Işıl
dc.date.accessioned2020-03-26T19:24:56Z
dc.date.available2020-03-26T19:24:56Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBACKGROUND: The objectives of the present study were to compare the effect of adjuvant chemotherapy for breast cancer on serum insulin levels, serum leptin levels, and body composition in early stage breast cancer patients. MATERIALS AND METHODS: 17 breast cancer patients underwent 6 cycles of docetaxel (75 mg), epirubicine (100 mg) and cyclophosphamide (500 mg) (TEC). Anthropometrical and foot-to-foot body fat analyzer BIA, serum glucose, insulin, lipids, HOMA-IR and leptin were compared pre- and post-treatment. RESULTS: There was no statistically significant weight gain after treatment; however, there was an overall trend toward weight gain (69.7 +/- 9.8 kg vs 71.03 +/- 9.8; P = 0.05). From baseline to the end of the study, percentage of body fat and body fat mass showed an upward trend at the end of chemotherapy (1%; 2 kg P > 0.05). Pre and post-treatment period, leptin was strongly correlated with insulin and HOMA-IR (Spearman's pre-T; r = 0.74; P < 0.001, r = 0.66; P = 0.004 post-T; r = 0.549; P = 0.022, r = 0.51; P = 0.036, respectively). Insulin levels were significantly increased in the post-treatment period (P < 0.05). On correlation analysis, post-T insulin levels were correlated with leptin, weight, fat-mass and fat percentage (Spearman's r = 0.549; P =. 022, r = 0.567; P = 0.018, r = 0.498, P = 0.042, r = 0.502; P = 0.040, respectively). DISCUSSION: High insulin and leptin levels, important factors that were previously shown to be related to breast cancer outcome, and insulin resistance may be increased in taxane based chemotherapy regimen. These data may have broad implications for diet and lifestyle strategies for the prevention and treatment of cancers.en_US
dc.identifier.doi10.4103/0019-509X.180836en_US
dc.identifier.endpage+en_US
dc.identifier.issn0019-509Xen_US
dc.identifier.issn1998-4774en_US
dc.identifier.issue1en_US
dc.identifier.pmid27146736en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage39en_US
dc.identifier.urihttps://dx.doi.org/10.4103/0019-509X.180836
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33756
dc.identifier.volume53en_US
dc.identifier.wosWOS:000375843500010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMEDKNOW PUBLICATIONS & MEDIA PVT LTDen_US
dc.relation.ispartofINDIAN JOURNAL OF CANCERen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBreast canceren_US
dc.subjectchemotherapyen_US
dc.subjectinsulinen_US
dc.subjectleptinen_US
dc.subjecttaxaneen_US
dc.titleLeptin, insulin and body composition changes during adjuvant taxane based chemotherapy in patients with breast cancer, preliminary studyen_US
dc.typeArticleen_US

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