Effects of two different doses of acetylsalicylic acid on serum nitric oxide, asymmetric dimethylarginine, and homocysteine levels in healthy volunteers

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dc.contributor.authorMehmetoglu, Idris
dc.contributor.authorKurban, Sevil
dc.date.accessioned2020-03-26T18:25:21Z
dc.date.available2020-03-26T18:25:21Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: To examine the effects of ASA on serum nitric oxide (NO), asymmetric dimethylarginine (ADMA), and homocysteine levels in healthy volunteers. Materials and methods: Totally, 26 apparently healthy volunteers were enrolled in the study. Of the participants, 13 (5F, 8M) received 100 mg of ASA daily and 13 (5F, 8M) received 150 mg of ASA daily for 2 months. Serum NO, ADMA, and homocysteine levels were measured before and 1 and 2 months after ASA treatment Serum NO, ADMA, and homocysteine levels were measured before and 1 and 2 months after ASA treatment. Results: ADMA levels of the group receiving 150 mg of ASA were significantly reduced after 2 months of treatment (P < 0.05). NO levels of both groups were slightly but not significantly increased and homocysteine levels of both groups were slightly reduced after ASA treatment compared to the baseline values. Conclusion: Our findings indicate that ASA treatment reduces ADMA levels dose and time dependently, a beneficial effect that may contribute to the prevention of cardiovascular diseases.en_US
dc.description.sponsorshipUniversity of Selcuk Scientific Research Department (BAP), Konya, TurkeySelcuk Universityen_US
dc.description.sponsorshipThis research was supported by the University of Selcuk Scientific Research Projects Department (BAP), Konya, Turkey. It was presented as a poster at the First European Joint Congress of EFCC and UEMS, 13-16 October, 2010, Lisbon, Portugal.en_US
dc.identifier.doi10.3906/sag-1012-1322en_US
dc.identifier.endpage274en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issn1303-6165en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage269en_US
dc.identifier.urihttps://dx.doi.org/10.3906/sag-1012-1322
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27996
dc.identifier.volume42en_US
dc.identifier.wosWOS:000301993300011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEYen_US
dc.relation.ispartofTURKISH JOURNAL OF MEDICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAcetylsalicylic aciden_US
dc.subjectnitric oxideen_US
dc.subjectasymmetric dimethylarginineen_US
dc.subjecthomocysteineen_US
dc.subjecthealthy volunteersen_US
dc.titleEffects of two different doses of acetylsalicylic acid on serum nitric oxide, asymmetric dimethylarginine, and homocysteine levels in healthy volunteersen_US
dc.typeArticleen_US

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