Plasma netrin-1 levels significantly increase in smokers

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dc.contributor.authorKizmaz, Muhammet
dc.contributor.authorMarakoglu, Kamile
dc.contributor.authorKiyici, Aysel
dc.contributor.authorAy, Emre
dc.date.accessioned2020-03-26T19:25:39Z
dc.date.available2020-03-26T19:25:39Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: Netrin-1 is a laminin like protein that has recently been suggested to involve in the pathophysiology of atherosclerosis and treatment targets. The relationship between netrin-1 and atherosclerosis has not been evaluated in a human research previously and the effect of smoking on plasma netrin-1 levels as well. In this study, we aimed to evaluate plasma netrin-1 levels in smokers and non-smokers and the impact of smoking on netrin-1 levels. Our second aim was to evaluate the existence of peripheral artery disease in these groups by means of ankle brachial index (ABI) measurements and the relation between plasma netrin-1 levels and peripheral artery disease. Design and Methods: Smoker and non-smoker male patients were contributed in the study, 112 males in each group. ABI of all patients was determined with an automatic device and plasma netrin-1 levels were quantified with an enzyme-linked immunosorbent assay. Netrin-1 levels were compared between smoker and non-smoker cases, and the cases with and without peripheral arterial disease. Results: Plasma netrin-1 levels of smokers (4.54 +/- 2.87 pg/mL) were significantly higher than in non-smokers (3.81 +/- 1.26 pg/mL) (p = 0.015). Similarly, netrin-1 levels of cases with peripheral arterial disease (6.21 +/- 2.16 pg/mL) were significantly higher than the ones without peripheral arterial disease (4.07 +/- 2.16 pg/mL) (p = 0.002). Amount of smoking (packet.year) and ABI were found to be significantly related with netrin-1 levels. The relationship between PAD and netrin-1 levels remained significant after adjusting for smoking status. Conclusion: We can conclude that plasma netrin-1 levels significantly increase in smokers and peripheral artery disease is significantly related with netrin-1 levels after adjusting for smoking status. (C) 2016 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipBAP [14102048]en_US
dc.description.sponsorshipThis research was granted by our institute (Scientific Research and Projects Coordinator, BAP, Project Number: 14102048).en_US
dc.identifier.doi10.1016/j.clinbiochem.2016.02.011en_US
dc.identifier.endpage834en_US
dc.identifier.issn0009-9120en_US
dc.identifier.issn1873-2933en_US
dc.identifier.issue10.11.2020en_US
dc.identifier.pmid26944719en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage832en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.clinbiochem.2016.02.011
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33883
dc.identifier.volume49en_US
dc.identifier.wosWOS:000378221800018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofCLINICAL BIOCHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNetrin-1en_US
dc.subjectAnkle brachial indexen_US
dc.subjectSmokingen_US
dc.subjectAtherosclerosisen_US
dc.titlePlasma netrin-1 levels significantly increase in smokersen_US
dc.typeArticleen_US

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