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Chemical Composition and Anticholinesterase Activity of Lagochilus Inebrians
(SPRINGER, 2019) Akramov, Davlat Kh.; Bacher, Marcus; Zengin, Gökhan; Böhmdorfer, Stefan; Rosenau, Thomas; Azimova, ‪Shakhnoz S.; Mamadalieva, Nilufar Z.
The plant genus Lagochilus (Lamiaceae) comprises 44 species that are broadly distributed over Central Asia with 18 species occurring in the flora of Uzbekistan [1]. Tincture of the herb and roots of L. inebrians Bunge, which is indigenous in Uzbekistan [2], are used in folk medicine as a sedative, analgesic, and hemostatic agent [3]. The hemostatic activity is due to the diterpene alcohol lagochilin. Hemostatic materials based on this compound were fabricated [4]. Diterpenes (lagochilin and its acetates) [5,6,7] and iridoids (8-O-acetylharpagide and harpagide) [8] were observed in L. inebrians. However, the chemical composition of this plant is inadequately studied. The enzyme-inhibiting activity has not been studied.