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Öğe Effect of Zinc and Melatonin Supplementation on Cellular Immunity in Rats With Toxoplasmosis(Humana Press Inc, 2003) Baltacı, Abdülkerim Kasım; Bediz, Cem Şeref ; Moğulkoç, Rasim; Kurtoğlu, Erdal; Pekel, AyselThe effects of zinc (Zn) and/or melatonin supplementation on cellular immunity were investigated in rats infested with Toxoplasma gondii. Fifty Sprague-Dawley male rats were used for this study. All animals were fed a normal diet, ad libitum, containing 97 mg Zn/kg. They were divided into five experimental groups, as follows. Group I (n = 10) received intraperitoneal injections of zinc sulfate at a dose of 3 mg/kg/d for 3 wk. Group II (n = 10) received intraperitoneal injections of melatonin at a dose of 3 mg/kg/d for 3 wk. Group III (n = 10) received intraperitoneal injections of zinc sulfate (3 mg/kg/d) and melatonin (3 mg/kg/d) for 3 wk. Group IV (n = 10) was infested controls. Group V (n = 10) was healthy controls. There were no differences in the percentage of CD3+ lymphocytes among all groups. For groups I-III, the CD4+ and CD8+ ratios were higher than those of the groups IV and V controls (p < 0.01). Similarly, the total lymphocyte ratios in groups I-III were higher than those of infested and healthy controls (p < 0.01). The total lymphocyte ratios in group III were significantly higher than those of groups I and 11 (p < 0.01). The plasma Zn levels in the supplemented groups were significantly higher than those of control groups IV and V (p < 0.01). These results suggest that melatonin and/or Zn supplementation may activate cellular immunity by stimulating CD4+ and CD8+ production in infected rats with T. gondii.Öğe Effects of Zinc and Melatonin Deficiency on Testicular Tissue of Rats(Humana Press Inc, 2003) Öztürk, Ahmet ; Baltacı, Abdülkerim Kasım ; Bediz, Cem Şeref; Moğulkoç, Rasim ; Güngör, SalimThe present study was designed to investigate the effects of zinc and/or melatonin deficiency on rat testes. A total of 24 adult male Sprague-Dawley rats were used in this study The rats were divided into four groups of six rats each, as follows: (I) controls, (II) zinc deficient, (III) pinealectomized, zinc normal, and (IV) pinealectomized, zinc deficient. The plasma zinc levels in the control group were higher than in all the other groups (p < 0.01), and those of the zinc-deficient groups II and IV were significantly lower than for group III (p < 0.01). The melatonin levels in the controls were also significantly higher than for all other groups (p < 0.01) There was no significant difference in sperm production between the controls and the group of animals that had no epiphysis. A significant suppression was observed in the spermatogenetic activity of the zinc-deficient groups (p < 0.01). The suppression was higher in group II than in group IV. These results indicate that testicular damage caused by zinc deficiency may be reduced by melatonin deficiency.Öğe For a Higher Sprint Running Performance, in Which Part of the Warm-Up Protocol Should the Dynamic Stretching Phase be Applied?(Selçuk Üniversitesi, 2023 Nisan) Günay, Erkan; Özçelik, Recep; Mancı, Egemen; Çetinkaya, Caner; Bediz, Cem ŞerefThe literature has frequently examined the acute effect of warm-up protocols on athletic performance components. The lack of evidence in static stretching studies led researchers to dynamic stretching protocols that simultaneously enhance basic skill level, kinaesthetic awareness, range of motion, and core temperature. However, it needed to be clarified in which part of the warming up the dynamic stretching phase should be done. This study investigated the acute effect of the dynamic stretching exercise phase before and after a warm-up on the 20m sprint performance. The study included forty-four soccer players, aged 16.59±1.06 years, who played for amateur teams. Participants were randomly divided into two groups on the first day of the study. In the first group, dynamic stretching was performed before warm-up (BGW), and the players' 20m sprint performances were tested. In the second group, dynamic stretching was performed after the warm-up (AGW), and the players' 20m sprint performances were tested. On the second day of the study, the same protocol was applied to the same players by changing groups of players. The average speed in the 20m sprint test of the BGW group (2.96±0,13 sec.) was found to be significantly shorter than the AGW group (3.01±0,12 sec., p<0.05). The difference in the 20 m speed test values between groups was significant (p<0.05). The findings obtained in the applied experimental condition show that the dynamic stretching protocol applied before the warm-up running phase increases the sprint running performance. It may be more beneficial for the performance of athletes to do dynamic stretching before sprint running performances.Öğe Pinealectomy and Zinc Deficiency Have Opposite Effects on Thyroid Hormones in Rats(Marcel Dekker Inc, 2003) Baltacı, Abdülkerim Kasım ; Moğulkoç, Rasim; Bediz, Cem Şeref; Kul, Aylin; Uğur, AyşegülThe present study was conducted to investigate how pinealectomy and zinc deficiency separately or in combination affected thyroid hormones in rats. The study was carried out on 40 Sprague-Dawley male rats. The rats were equally allocated to four groups: Group 1 (control group), Group 2 (zinc-deficient group), Group 3 (pinealectomized group) and Group 4 (pinealectomized and zinc-deficient group). At the end of a 4-week study period, the rats were decapitated and blood samples were taken. The samples were examined in terms of plasma zinc, melatonin, free and total T-3, T-4, and TSH. It was found that free T-3 and T-4 levels in the pinealectomized group (Group 3) were higher than all others (p < 0.01) while free T-3, T-4, and TSH levels in the zinc-deficient group (Group 2) were lower than all others (p < 0.01). Free T3 and T4 levels in the pinealectomized zinc-deficient group (Group 4) were lower than those in Groups I and 3 and higher than those in Group 2 (p < 0.01). The findings obtained at the end of the study period show that pinealectomy has a stimulating and zinc deficiency has a suppressing effect on thyroid hormones and that the suppressing effect caused by zinc deficiency is partially balanced by pinealectomy.Öğe Sekonder Hiperparatiroidizmli Hemodiyaliz Hastalarında Kalsitriol Tedavisinin Retinadaki Etkisinin Desen Değişimli Görsel Uyarıya Kortikal Cevap ile Araştırılması(2000) Özkağnıcı, Ahmet; Gündüz, Kemal; Türk, Süleyman; Bediz, Cem Şeref; Akbulut, MehmetAMAÇ: Kronik böbrek yetmezliği olan bir grup hasta incelenerek sekonder hiperparatiroidizmde kalsitriol tedavisinin fotoreseptör ve ganglion hücrelerindeki etkisinin görsel uyarıya kortikal cevap yöntemi ile araştırılması. YÖNTEM: Kalsitriol tedavisinden önce ve sonra %80 ve %40 kontrastta, 46' ve 23' ebadında siyah-beyaz kare uyaran 2 Hz frekansta hareket ettirilerek görsel uyarıya kortikal cevap latens ve genlikleri incelendi. Kalsiyum metabolizması ile görsel uyarıya kortikal cevap verileri arasında bir yaklaşım oluşturularak kalsitriol'ün fotoreseptör ve ganglion hücrelerindeki etkisi araştırıldı. BULGULAR: Altı ay süre ile verilen kalsitriol tedavisinden sonra görsel uyarıya kortikal cevap genliklerinde bütün parametrelerde anlamlı farklar, latenslerde ise sadece düşük kontrastta anlamlı farklar bulundu. SONUÇ: Kalsitriol tedavisi ile bozulmuş kalsiyum metabolizmasının kontrol altına alınabildiği ancak retina üzerindeki etkisinin henüz belirsiz olduğu düşünülmektedir.
