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    ABM/P-15 modulates proliferation and mRNA synthesis of growth factors of periodontal ligament cells
    (TAYLOR & FRANCIS LTD, 2009) Emecen, Pinar; Akman, Abdullah Cevdet; Hakki, Sema Sezgin; Hakki, Erdogan Esref; Demiralp, Burak; Toezeum, Tolga Fikret; Nohutcu, Rahime Meral
    Objective. Periodontal regeneration is histologically defined as regeneration of the tooth supporting structures, including alveolar bone, periodontal ligament, and cementum. Cells in the remaining periodontal tissues need optimal conditions if they are to perform their functions in the regeneration process. The present study is an investigation of the molecular effects of ABM/P-15 on human periodontal ligament cells (PDL) in vitro. Material and methods. PDL cells obtained from healthy subjects were used for in vitro experiments. Cell proliferation, morphology, and mineralization using Von kossa staining were evaluated. mRNA expressions for transforming growth factor- (TGF-), insulin-like growth factor-I (IGF-I), basic fibroblast growth factor (b-FGF), vascular endothelial growth factor (VEGF), bone morphogenic protein-2 (BMP-2), platelet-derived growth factor (PDGF), and type 1 collagen (COL1) were assessed on days 3 and 7 using RT-PCR. Results. ABM/P-15 enhanced proliferation of cultured PDL cells. It increased the mRNA expression of TGF- and BMP-2 in cultured PDL cells on days 3 and 7. IGF-I and b-FGF mRNA expressions showed a slight decrease, while PDGF expression was observed to have increased on day 3. VEGF and COL1 mRNA expressions were found not to be different on days 3 and 7. No differences were observed in the mineralization properties of cultured PDL cells treated with or without ABM/P-15. Conclusions. Based on the results of this in vitro study, it may be concluded that ABM/P-15 enhanced the regenerative capacity of PDL by regulating specific gene expressions of cells during early wound healing.
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    Clinical and Radiographical Analysis of Single-Tooth Replacement with Swissplus Implant System
    (2006) Demiralp, Burak; Muhtaroğulları, Mehmet; Ertan, A. Atila; Hakkı, Sezgin Sema
    Purpose: The purpose of this study was to provide a report of experience and results with Swissplus implant system used for single-tooth treatment. Materials and Methods: 62 single-tooth implants (30 maxilla, 32 mandible) were placed in 42 patients (22 females, 20 males; aged between 20 to 69 with a mean age of 38.6 ± 13.2 years) over a period of 30 months. All crowns were cemented on standard abutments. The follow-up time varied between 3 to 30 months. Radiographical bone loss, peri-implant soft tissue conditions including gingival index, plaque index and pocket depths have been evaluated Results: One implant (%1.61) was lost before loading. 5 crowns (% 8.1) were recemented due to the loosing. Peri-implant soft tissue conditions were satisfactory. Pocket depths were 2.8 ± 1.4 mm and bone resorption was 0.8 ± 0.4 mm over a period of 30 months. Discussion: Based upon a clinical study of 62 single tooth implants placed over a period of 30 months an implant survival rate of %98.4 was observed. With a %98.4 survival rate of Swissplus implant system in single-tooth replacement were satisfactory.
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    The effect of different cleaning methods on the surface and temperature of failed titanium implants: an in vitro study
    (SPRINGER LONDON LTD, 2017) Hakki, Sema S.; Tatar, Gulsah; Dundar, Niyazi; Demiralp, Burak
    The aims of this in vitro study are to compare the efficacy of different cleaning methods in removing debris of failed implants and to detect thermal changes of the implants treated by various scaling instruments. Twenty-seven failed implants and two unused implants as control were included to this study-group 1: plastic curette (P), group 2: titanium curette (T), group 3: carbon curette (C), group 4: titanium brush (TB), group 5: Er:YAG laser (laser 1 (L1) 100 mJ/pulse at 10 Hz), group 6: Er:YAG laser (laser 2 (L2) 150 mJ/pulse at 10 Hz), group 7: Er:YAG laser (laser 3 (L3) 200 mJ/pulse at 10 Hz), group 8: ultrasonic scaler appropriate for titanium (US), group 9: air abrasive method (AA) + citric acid, and group 10: implantoplasty (I). The changes on the treated/untreated titanium surfaces and remnant debris were observed by scanning electron microscopy (SEM). Temperature of the implants before and after treatment was detected using a thermocouple. The use of air abrasive and citric acid combination and Er:YAG laser groups was found as the best methods for the decontamination of titanium surfaces of failed implant. When the hand instruments were compared, titanium curette was found better than both the plastic and the carbon curettes which leave plastics and carbon remnants on the titanium surface. The temperature was higher after hand instrumentation when compared to other experimental groups (p < 0.05). Within the limitations of the present in vitro model, it can be concluded that the best method for decontamination of the implant surface is the use of air abrasives and Er:YAG laser.