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  • Küçük Resim
    Öğe
    Amigdalin ile Zehirlenen Koyunlarda Siyanür ve Tiyosiyanatın Rumen Sıvısı ve Kandaki Bazı Toksikokinetik Parametrelerinin Araştırılması
    (Selçuk Üniversitesi, 1998) Pirinçci, İbrahim; Tanyıldızı, Sadettin; Kaya, Sezai; Yarsan, Ender; Özaydın, Songül
    This investigalion was carried out lo establish some toxicokineıic parameters of the eyanide in rumen liquor and eyanide and ıhiocyanate in blood ol ıhe sheep experimenıally poisoned with amygdalin. In this study , 20 sheep 40 - 50g weights were used. Amygdalin was givcn oraJly in doses ol 0.25, 0.5, 1 and 1.5 m9'k;g. The eyanide and Ihi· ocyanate levels in samples were determined. Then some toxicokinetic paramelers of the eyanide and Ihiocyanate like as the distribution half-life, the elimination half-life, mean residence times and area under Ihe curve (AUC) in rumen liquor and the blood samples laken at 0.5, 1, 2, 4, 8, 24, 48 and 72 Ih hours were eslablished. The distribution half· lifes ol eyanide levels in rumen liquor were respectively, 0.18iO.009, 0.14iO.Ol. 4.66iO.l1 and 4.82tO.17.hours; the elimination half-lifes were respectively, 17.22±O.66, 14.8O±O.43, 9.21iO.16 and 9.66iO.40 hours; AUe values ac· cording lo doses were respeclively, 30.68±O.65, 3O.04iO.24, 38.57iO.22 and 39.29±O.17 mg.hour/ml were observed. Besides mean residence times were respectively. 26.52±1.01, 23.66iO.33, 19.55iO.12 and 19.72±O.3S hours; the duration ol maximal eyanide concentration were respeclively, 2, " 8 and 8th hour; and the maximal eyanide levels ac· cording to were respeclively, 0.983. 1.025, 1.241 and 1.225 ?glml were determined. The distribution half-liles of blood eyanide levels were respectively, O. IStO.OS. 0.42±O.04, 1.4S±2.05 and 9.73±3.74 hours; the elimination hall·lifes were respectively, 59.48±4.40, 55.12±42.66, 70.77±4.10 and 48.05±19.27 hours; and AUe values according lo doses were respectively, ı8.45iO.85. 45.10±21.14, 27.45±2.02 and 2S.76±2.77 Jl9.hour/ml were established. Besides mean residence times ol eyanide levels in blood were respectively, B7.56t5.93, 86.94t54.02, 105.93t7.25 and 75.21±23.10 hours; the duraıion ol maximal concentration 1 hours; and the maximal blood levels according to doses were respeclively, 0.165, 0173, 0.166 and 0.210 mgfml were delermined. The distribution hatf-lifes of blood Ihiocyanate levels were respeclively, 2.05tl.45, O. t6iO.05. O. t7iO.04 and O.29±O.13 hours; the elimination half-liles were respectively, BB.93±2S.08, 73.21±19.44. BO.2BtıOAl and BO.81±15.26 hours; AUe values were respectively, B.60±6.42, 7.47±2.40, 7.14tl.02 and 10.67±3.55 Jlg.hour/ml; and mean residence times according to doses were respectively, 130.56t36.4B, 107.20±27.54. 1 t7.23t14.65 and 117.67±22.01 hours were calculated. Besicles, the duralion ol maximal eoneentralion " 2, 2 and 2 hours; and the maximal blood levels according to doses were respectively, 0.064,0.056, 0.066 and 0.056 mgml were determined.
  • Küçük Resim
    Öğe
    Pharmacokinetics of Enrofloxacin After Intravenous and Intramuscular Administration in Angora Goats
    (CANADIAN VET MED ASSOC, 2001) Elmas, Muammer; Traş, Bünyamin; Kaya, Sezai; Baş, Ahmet Levent; Yazar, Enver; Yarsan, Ender
    Pharmacokinetics and bioavailability of enrofloxacin were determined after single intravenous (IV) and intramuscular (IM) administrations of 5 mg/kg body weight (BW) to 5 healthy adult Angora goats. Plasma enrofloxacin concentrations were measured by high performance liquid chromatography. Pharmacokinetics were best described by a 2-compartment open model. The elimination half-life and volume of distribution after IV and IM administrations were similar (t(1/2 beta), 4.0 to 4.7 h and V-d(ss),1.2 to 1.5 L/kg, respectively). Enrofloxacin was rapidly (t(1/2a), 0.25 h) and almost completely absorbed (F, 90%) after IM administration. Mean plasma concentrations of enrofloxacin at 24 h after IV and IM administration (0.07 and 0.09 mug/mL, respectively) were higher than the minimal inhibitory concentration (MIC) values for most pathogens. In conclusion, once-daily IV and IM administration of enrofloxacin (5 mg/kg BW) in Angora goats may be useful in treatment of infectious diseases caused by sensitive pathogens.
  • Küçük Resim
    Öğe
    Siyanür ve Tiyosiyanatın Bazı Toksikokinetik Parametreleri Üzerine Kobalt Klorürün Etkisinin Araştırılması
    (Selçuk Üniversitesi, 1998) Traş, Bünyamin; Pirinçci, İbrahim; Tanyıldızı, Sadettin; Kaya, Sezai
    This study was made to determine the same toxicokinetic parameters of eyanide and thiocyanate in sheep experimentally poisoned with amygdalin. In this study. LS sheep 50 - 60 kg weights were used. Amygdalin and cobalt chloride were given and the eyanlde and thioeyanate levels in samples were determined Then some ıoxicokinetic paramelers of Ihe eyanide and Ihioeyanaıe in the blood samples laken al 0.5. 1, 2. 4. 8, 24. 48 and 72 ın hours were established. The cobalt chloride was given intravenously in doses 5 and İS mçVkg and then the distribution half-lives of blood eyanide levels according to doses were respectively, 3.17±O.35 and 4.03±O.65 hours; the elimination half-lives were respectively, 27.62±3.16 and 39.53±5.35 hours; mean residence times were respectively, 44.44±2.76 and 109.29±8.43 hours; Ihe duratlon of maximat coneentration were respectively, 241h hours; the maximal blood levels were respectively, 0.120 and 0128 glml were determined. Besides, area under the curve values according to doses were respectively, 7.09±1.24 and 5.93±O.64 mg. hour/ml; volumes of distribution at steady state were respectively, 0.099±O.OO5 and 0.125iO.Ol l/kg; clearanee values were respeclively, 1.21iO.44 and 2.52±1.21 mVhour. kg were calculated. The distribution half-Ilves of blood thioeyanaıe levels according lo doses were respeclively. 0.30±0.02 and 2.49±1.12 hours; the eliminatian half-lives were respectively, 213.89±11.21 and 96.56±9.35 hours; mean residence times were respectively, 309.09±25.76 and 142.95±15.66 hours; the duralian of maximal concentration were respectively, 2 and ı lh hours; the maximal blood levels were respectively, 0.028 and 0.032 glml were determined. Besides, area under the curve values according lo doses were respeclively, 8.77±1.44 and 3.26t1.5S J.lg. hour/ml; volumes of distribution al steady state were respectively, 0.211iO.Ol and 1.333iO.05 l/kg;; cleararıce values were respectively. 0.56iO.23 and 7.66±1.55 mVhour. kg were established.
  • Küçük Resim
    Öğe
    Siyanür ve Tiyosiyanatın Farelerde Bazı Toksikokinetik Parametrelerinin Araştırılması
    (Selçuk Üniversitesi, 1998) Traş, Bünyamin; Tanyıldızı, Sadettin; Pirinçci, İbrahim; Kaya, Sezai; Yersan, Ender
    The purpose ol lhis study was lo deıermine the some toxicookinetic parameters ol eyanide and thiocyanaıe in mice experimentally poisoned wilh sodium eyanide. In the study, 200 mice, 40-50 g weights, were used. Sodium eyanide were given intraperiıoneally in doses ol 0,1, 0.2, 0.4 and 0.8 mglkg. Then, some to)(icokinetic parameters ol the eyanide and thiocyanate like as distribution half-lile, elimination half-life, mean existence lime and area under the curve (AUC) in the blood samples drawn at 6,12,30,60,120,240,360 ve 720th minules were determined. The distribution half-lifes ol blood eyanide levels were. respectively, 0.04±O.02, 0.05±O.009. 0.06±O.OO8 and 0.08±O.01th hour; the elimination hall-liles were, respectively, 3.06±O.14, 2.36±O.02, 2.33±O.03 and 2.28±O.06 hours; the duration ol ma)(imat concentraıion was 12 minules and the ma)(imal blood levels, according to doses, respeclively, were 0.153, 0.308, 0.350 and 0.376 ).lg/ml. Besides. mean e)(islence times were, respectively, 4.53±O.20, 3.5O±O.03, 3.46±O.05 and 3.43±O.12 hours and AUC values accordıng to doses were, respectively, 33.50±2.62, 45.40±1.84, 48.91±2.77 and 58.47±2.54 ?ıg.hour/ml were observed. The distribution half-liles ol blood thiocyanate levels were, respectively, 0.07±Q.OO8, 0.09±O.OO5, 0.09±O.OO5 and 0.18±O.05 hours; the elimination hall-liles were, respectively, 62.8O±19.36, 25.79±2.65, 14.48±0.41 and 14.53±O.80 hours; the duralion ol ma)(imal corlCentration 120 minutes and Ihe maximal blood levels according ıo doses were, respectively, 0.265, 0246, 0.408 and 0.444 ).lg/ml. Besides, mean exislence times were, respectively, 90.27±27.95, 37.37±3.83, 21.04±O.59 and 21.27il.17 hours and AUC values according to doses were, respectively, 79. 13±54. 19, 28.Q6±15.38, 8.92±0.45 and 89.22±49.91 ).Ig.hourfml.
  • Küçük Resim
    Öğe
    Siyanür ve Tiyosiyanatın Toksikokinetiği Üzerine Sodyum Nitritin Etkilerinin Araştırılması
    (Selçuk Üniversitesi, 1998) Tanyıldızı, Sadettin; Pirinçci, İbrahim; Kaya, Sezai; Baydan, Emine
    This study was carried out to determine the effects of sodium nitrites on some toxicoklnetic parameters ol eyanide and thiocyanate in sheep experimentally poisoned with amygdalin In this study, 18 sheep 50 -60 kg weights were used. Amygdalin and sodium nitrite were given and the cyanide and thiocyanate levels in samples were delermined Then some toxicokinetic parameters ol the eyanide and thiocyanate in the blood samples taken at 0.5, 1,2, 4, 8, 24, 48 and 72 th hours were established. The sodium nitrite was given intravenously in doses 5 and 25 mglkg and then the distribution hall-lives of blood eyanide levels according to doses were respectively, 0.23±O.01 and 3.14±1.65 hours; the elimination hall-lives were respectively, 60.80±13.41 and 126±24.33 hours; mean residence times were respectively, 88±10.04 and 18S±2S.21 hours; the duration ol maximal concentration were respectively, 48th hour; the maximal blood levels were respectively, 0.151 and 0148 ?g1ml were determined. Besides, area under the curve values were according to doses were respectively, 11.28±1.24 and 9±S.62 ?g.hour'ml; volume of distribution at steady slate were respectively, 0.03±O.OOI and 0.2±0.03 Ukg; clearance values were respectively, 0.44±O.12 and 0.16±O.09 ml/hour.kg were calculated. The distribution half-lives of blood thiocyanaıe levels according lo doses were respectively, 18.30±2.21 and 29.44±3.41 hours; the elimination half-lives were respectively, 224.43±11.40 and 42.89±8.85 hours; mean residence times were respectively, 137.36±24.2 and 64.38±6.6S hours; the duration of maximal concentration were respectively, 24 and 48th hours; the maximal blood levels were respectively, 0.026 and 0.028 ?g1ml were detennined. Besides, area under the curve values according lo doses were respectively, 4.66±O.21 and 9.82±O.8 ?g.hour/ml; volume ol distribution at steady state were respectively, 0.147±O.03 and 0.162±O.03 Ukg; clearance values were respectively, 1.07±O.31 and 7.72±2.84 mVhour.kg were established .
  • Küçük Resim
    Öğe
    Siyanür ve Tiyosiyanatın Toksikokinetik Üzerine Sodyum Tiyosülfatin Etkilerinin Araştırılması
    (Selçuk Üniversitesi, 1998) Traş, Bünyamin; Pirinçci, İbrahim; Tanyıldızı, Sadettin; Kaya, Sezai
    This study was made lo delermine the some loxicokinetic parameters of eyanide and thiocyanate in sheep experimentally poisoned with amygdalin In this study, 24 sheep 50 · 60 kg weights were used. Amygdalin and sodium thiosulfale were given and tha eyanide and Ihiocyanate levels in samples were determined Then some toxicokinetic parameters ol lhe eyanide and thiocyanate in the blood samples taken al 0.5, 1,2,4, 8, 24, 48 and 72 th hours were established. The sodium Ihiosullale wera given intravenously in doses 50 and 600 mg!kg and lhen the distribution halllivas ol blood eyanide lavals ware respectively, 0.57±O.05 and 3.24±O.16 hours; the elımination halllives were respectively, 172.93tl1.4 and 77.08tI5.26 hours: mean residence times were respectivety, 250.37±25.2 and 102.1 0i8.12 hours; the duralion of maximal concentration were respectively, 48th hour; the maximal blood levels respectively, 0.177 and 0.186 ,ıg/ml were determıned. Besides. area under the curve values according to doses were respeclively. 26.68±2.18 and 14.20±1.94 Ilg.hour/ml: volume ol distribution at steady state were respectivety, 0.371±O.01 and 4.312±O.77 lJkg: clearance values were respectively, 1.87t1.10 and 42.23t5.64 mVhour.kg were calcutated. The dislribution half·llvas ol blood thiocyanate levels according lo doses were respectivety, 0.44±O.03 and 0.48±O.05 hour; the eliminalion hall·lives were respeclively, 56.17t5.34 and 128.24±8.43 hours; mean residanca times were respectivety, 81.69±4.47 and 152.11±11.6 hours; the duralion ol maximal concentratiorı respectivety, 24 and 21h hours; the maximal blood levels were respeClively, 0.03 and 0.05 Ilg/ml were determined. 8esides, area under the curve values according to doses were respectively, 2.10t0.05 and4.31±O.04llg.hour/mt; volume ol distribution at steady state were respectivety, 1.89±O.03 and 21.278±1.88 lIkg: clearance values were respectivety, 23.75;t6.40 and 139.16t51.7 mVhour.kg were established.