Pharmacokinetics of Enrofloxacin After Intravenous and Intramuscular Administration in Angora Goats

Pharmacokinetics and bioavailability of enrofloxacin were determined after single intravenous (IV) and intramuscular (IM) administrations of 5 mg/kg body weight (BW) to 5 healthy adult Angora goats. Plasma enrofloxacin concentrations were measured by high performance liquid chromatography. Pharmacokinetics were best described by a 2-compartment open model. The elimination half-life and volume of distribution after IV and IM administrations were similar (t(1/2 beta), 4.0 to 4.7 h and V-d(ss),1.2 to 1.5 L/kg, respectively). Enrofloxacin was rapidly (t(1/2a), 0.25 h) and almost completely absorbed (F, 90%) after IM administration. Mean plasma concentrations of enrofloxacin at 24 h after IV and IM administration (0.07 and 0.09 mug/mL, respectively) were higher than the minimal inhibitory concentration (MIC) values for most pathogens. In conclusion, once-daily IV and IM administration of enrofloxacin (5 mg/kg BW) in Angora goats may be useful in treatment of infectious diseases caused by sensitive pathogens.

La phairmacocinL3tiq1e et /a biodispoiiibilite de /'enirofloxaciniefuirenit determintees sluite n liune adminiistrationi uniiiqlue par voic inztraveinielise (IV) on intramuiiiscldaire (IM) diu niedicamen t d lone dose de 5 mtg/kg de poids corporel (p.c.) d cinq chevres Angora adl iltes en sanWt. Les concentrationis plasmlatiques d'enrofloxacinefitrent miesurees par chroniatographie de hallte performance en phase liquide. Un mlodde oilvert d deuix compartimnents decrit le mieux /a pharmacocinttiqule de /'enrofloxacinie. La demni-vie d'limibinationi et le vol/nie de distriblution apres administrationi IV olu IM etaient sim ilaires et respectivenment de t ,1),, 4,0-4,7 h et Va,, 1,2-1,5 L/kg. L'enrofloxacintefit rapidemtent (t 11,71, 0,25 h) et presqlue coam plktenient (F, 90 %) absorbee apres adnministrationt IM. Les concentrations plasniatiquies moyennes d'enrofloxacine 24 hi apres admiinistrationi IV et IM etaient respectivement de 0,07 et 0,09 Lg/niL et etaient plus levees quie /a concentrationi niinimale inihibitrice de /a pll/part des mlicro-organ ismes pathogenes. En conclusioni, itnie admiinistration qluotidienne par voie IV otl IM d'enrofloxacinie n la dose de 5 mug/kg p.c. c/iez des chevres Angora polurrait s'averer lutile polur le traitemlent de nialadies infectielnses canisLes par des bacteries pat hogMnes sensibles.