Pharmacokinetics of Enrofloxacin After Intravenous and Intramuscular Administration in Angora Goats

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dc.contributor.authorElmas, Muammer
dc.contributor.authorTraş, Bünyamin
dc.contributor.authorKaya, Sezai
dc.contributor.authorBaş, Ahmet Levent
dc.contributor.authorYazar, Enver
dc.contributor.authorYarsan, Ender
dc.date.accessioned2020-03-26T16:37:18Z
dc.date.available2020-03-26T16:37:18Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPharmacokinetics and bioavailability of enrofloxacin were determined after single intravenous (IV) and intramuscular (IM) administrations of 5 mg/kg body weight (BW) to 5 healthy adult Angora goats. Plasma enrofloxacin concentrations were measured by high performance liquid chromatography. Pharmacokinetics were best described by a 2-compartment open model. The elimination half-life and volume of distribution after IV and IM administrations were similar (t(1/2 beta), 4.0 to 4.7 h and V-d(ss),1.2 to 1.5 L/kg, respectively). Enrofloxacin was rapidly (t(1/2a), 0.25 h) and almost completely absorbed (F, 90%) after IM administration. Mean plasma concentrations of enrofloxacin at 24 h after IV and IM administration (0.07 and 0.09 mug/mL, respectively) were higher than the minimal inhibitory concentration (MIC) values for most pathogens. In conclusion, once-daily IV and IM administration of enrofloxacin (5 mg/kg BW) in Angora goats may be useful in treatment of infectious diseases caused by sensitive pathogens.en_US
dc.description.abstractLa phairmacocinL3tiq1e et /a biodispoiiibilite de /'enirofloxaciniefuirenit determintees sluite n liune adminiistrationi uniiiqlue par voic inztraveinielise (IV) on intramuiiiscldaire (IM) diu niedicamen t d lone dose de 5 mtg/kg de poids corporel (p.c.) d cinq chevres Angora adl iltes en sanWt. Les concentrationis plasmlatiques d'enrofloxacinefitrent miesurees par chroniatographie de hallte performance en phase liquide. Un mlodde oilvert d deuix compartimnents decrit le mieux /a pharmacocinttiqule de /'enrofloxacinie. La demni-vie d'limibinationi et le vol/nie de distriblution apres administrationi IV olu IM etaient sim ilaires et respectivenment de t ,1),, 4,0-4,7 h et Va,, 1,2-1,5 L/kg. L'enrofloxacintefit rapidemtent (t 11,71, 0,25 h) et presqlue coam plktenient (F, 90 %) absorbee apres adnministrationt IM. Les concentrations plasniatiquies moyennes d'enrofloxacine 24 hi apres admiinistrationi IV et IM etaient respectivement de 0,07 et 0,09 Lg/niL et etaient plus levees quie /a concentrationi niinimale inihibitrice de /a pll/part des mlicro-organ ismes pathogenes. En conclusioni, itnie admiinistration qluotidienne par voie IV otl IM d'enrofloxacinie n la dose de 5 mug/kg p.c. c/iez des chevres Angora polurrait s'averer lutile polur le traitemlent de nialadies infectielnses canisLes par des bacteries pat hogMnes sensibles.
dc.identifier.citationElmas, M., Traş, B., Kaya, S., Baş, A. L., Yazar, E., Yarsan, E., (2001). Pharmacokinetics of Enrofloxacin After Intravenous and Intramuscular Administration in Angora Goats. Canadian Journal of Veterinary Research-revue Canadienne De Recherche Veterinaire, 65(1), 64-67.
dc.identifier.endpage67en_US
dc.identifier.issn0830-9000en_US
dc.identifier.issue1en_US
dc.identifier.pmid11227198en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage64en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17588
dc.identifier.volume65en_US
dc.identifier.wosWOS:000166782100012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorElmas, Muammer
dc.institutionauthorTraş, Bünyamin
dc.institutionauthorBaş, Ahmet Levent
dc.institutionauthorYazar, Enver
dc.language.isoenen_US
dc.publisherCANADIAN VET MED ASSOCen_US
dc.relation.ispartofCanadian Journal of Veterinary Research-revue Canadienne De Recherche Veterinaireen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titlePharmacokinetics of Enrofloxacin After Intravenous and Intramuscular Administration in Angora Goatsen_US
dc.typeArticleen_US

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