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    Chemical Composition and Anticholinesterase Activity of Lagochilus Inebrians
    (SPRINGER, 2019) Akramov, Davlat Kh.; Bacher, Marcus; Zengin, Gökhan; Böhmdorfer, Stefan; Rosenau, Thomas; Azimova, ‪Shakhnoz S.; Mamadalieva, Nilufar Z.
    The plant genus Lagochilus (Lamiaceae) comprises 44 species that are broadly distributed over Central Asia with 18 species occurring in the flora of Uzbekistan [1]. Tincture of the herb and roots of L. inebrians Bunge, which is indigenous in Uzbekistan [2], are used in folk medicine as a sedative, analgesic, and hemostatic agent [3]. The hemostatic activity is due to the diterpene alcohol lagochilin. Hemostatic materials based on this compound were fabricated [4]. Diterpenes (lagochilin and its acetates) [5,6,7] and iridoids (8-O-acetylharpagide and harpagide) [8] were observed in L. inebrians. However, the chemical composition of this plant is inadequately studied. The enzyme-inhibiting activity has not been studied.
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    Comparative study on the chemical composition and biological activities of the essential oils of three Lagochilus species collected from Uzbekistan
    (TAYLOR & FRANCIS LTD, 2019) Akramov, Davlat Kh.; Zengin, Gökhan; Kang, Sun Chul; Tojibaev, Komiljon Sh.; Mahomoodally, Mohamad Fawzi; Azimova, Shahnoz S.; Mamadalieva, Nilufar Z.
    Lagochilus species are mainly distributed in Central Asia and widely used in folk medicine as a sedative and haemostatic. The present investigation reports on the extraction by hydrodistillation and the chemical composition of three Lagochilus species (L. gypsaceus, L. inebrians and L. setulosus) essential oils from Uzbekistan. The chemical composition of these essential oils was determined by GC-MS. The results showed that the studied essential oils are made up mainly of linalool (11.97%), beta-ionone (11.75%), trans-chrysanthenyl acetate (7.15%), alpha-terpineol (7.40%) for L. gypsaceus; trans-chrysanthenyl acetate (9.40%), eugenol (7.01%), trans-verbenol (3.85%), bicyclo[3.1.1]hept-3-en-2-one (3.76%), pinocarvone (3.43%) for L. inebrians; and finally 2,4-bis(1,1-dimethylethyl)phenol (19.78%), bicyclo[3.1.1]hept-2-en-4-ol (5.43%), hexadecanoic acid (5.39%), limonene (5.19%), 2-hexenal (5.03%) for L. setulosus. The best antioxidant and tyrosinase inhibitory activity was observed for the essential oil of L. inebrians. However, L. setulosus essential oil exhibited the strongest inhibitory effect against amylase.
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    Flavone glucosides from Artemisia juncea
    (TAYLOR & FRANCIS LTD, 2019) Okhundedaev, Bakhodir S.; Bacher, Markus; Mukhamatkhanova, Rimma F.; Shamyanov, Ildar J.; Zengin, Gökhan; Boehmdorfer, Stefan; Mamadalieva, Nilufar Z.; Rosenau, Thomas
    A new flavone glucoside, 4 ',5-dihydroxy-3 ',5 ',6-trimethoxyflavone-7-O-beta-D-glucoside was obtained from aerial parts of Artemisia juncea, together with the known flavone eupatilin (5,7-dihydroxy-3 ',4 ',6-trimethoxyflavone). The compounds were comprehensively analytically characterized by IR, UV, NMR and HR-MS, and their chemical structures ascertained. The EtOAc fraction of A. juncea showed the strongest DPPH radical scavenging ability as well as reducing power (in CUPRAC and FRAP assays) and phosphomolybdenum activity. This fraction also exhibited the strongest inhibitory effects on tyrosinase. Additionally, the best antidiabetic effects were observed for eupatilin and the CHCl3 fraction. [GRAPHICS] .
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    Phytochemical and biological activities of Silene viridiflora extractives. Development and validation of a HPTLC method for quantification of 20-hydroxyecdysone
    (ELSEVIER SCIENCE BV, 2019) Mamadalieva, Nilufar Z.; Boehmdorfer, Stefan; Zengin, Gökhan; Bacher, Markus; Potthast, Antje; Akramov, Davlat Kh.; Janibekov, Abdulaziz; Rosenau, Thomas
    Silene viridifiora (Caryophyllaceae) has adaptogen, tonic, actoprotector and immunomodulator properties that are mainly attributed to ecdysteroids. The aim of the present study is to investigate the chemical constituents of essential oil as well as the 20-hydroxyecdysone content in the methanol extract S. viridiflora and its related biological activity. GC-MS analysis showed the essential oil of S. viridifiora to have a complex composition, which was dominated by methyl palmitate (8.05%), 3-hexen-1-ol (7.54%), 3-hexenyl benzoate (3.86%), beta-myrcene (3.80%), 1,1-diethoxy-2-phenylethane (3.65%), hexahydrofarnesyl acetone (3.20%) and 4-terpineol (2.47%). A high performance thin-layer chromatography (HPTLC) method was developed to analyze the methanolic extracts of S. viridifiora and to quantify the main ecdysteroid, 20-hydroxyecdysone. Validation showed that the method was accurate over the entire calibration range and resulted in errors of less than 10% in the 100-815 mu g/ml concentration range. Antioxidant and enzyme inhibitory potentials of methanol extract and individual compounds of S. viridiflora were evaluated. The results could provide a starting point for designing novel phyto-pharmaceuticals.